WSEAS Transactions on Information Science and Applications
Print ISSN: 1790-0832, E-ISSN: 2224-3402
Volume 20, 2023
Designing a Histological Analyzer for Diagnosing Pathomorphological Changes in Tissues as an Example of Chlamydial Infection
Authors: , , , ,
Abstract: The article is devoted to the development of a device to study tissue destruction caused by damage to the histo-hematic barriers of the body, under the influence of chlamydial infection. Cell pathology refers to changes in its components and ultrastructures with causal relationships. Chlamydiacea is a spectrum of diseases that, because of their polymorphism, cannot be united by a specific symptom complex, and sometimes affect all systems and organs. Due to the lack of organotropy and host specificity of the different representatives of chlamydiae, the clinic of chlamydiae is extremely diverse. The pathological process in chlamydial infections may localize in many organs, thus causing pathomorphologic changes in various body structures. The complex of adequate and modern methods of investigation makes it possible to evaluate the changes occurring in the macroorganism at the cellular and ultrastructural level. Emerging dystrophic, dyscirculatory, inflammatory processes in general, while not specific for chlamydia, are complemented by signs pathognomonic for this infection (presence of chlamydial antigens in cells in immunohistochemical method of study, detection of chlamydial structures in cells in electron microscopy). Currently, automation and robotization of research are penetrating all areas of medicine and veterinary medicine, including histological analysis. Currently, in the preparation of histological preparation, the technological process is automated in a fragmented way. The development of a histology robot will help to solve the problem of the shortage of highly qualified histology lab technicians and pathologists and reduce the burden on medical personnel in general. Processes of automation and modeling of technological flows and resources in the preparation of histological images and acceptance of the diagnosis in medicine and veterinary medicine is an urgent tasks. In order to identify pathological processes at the cellular level, as well as to reduce the error in the performance of histological manipulations, approaches to the design of a histological robot were developed. The model of the express analyzer structurally consists of two modules: a histological image preparation module and a pathology recognition module. Laboratory experiments were carried out to identify indicators of pathologies. Software for programmed OMRON controllers has been developed. Analysis of the simulation of the circuit operation showed positive results. The probability of pathology recognition was 0.8-0.9.
Search Articles
Pages: 154-162
DOI: 10.37394/23209.2023.20.18