Vladimir K. Mukhomorov, "Statistical Modeling of Antiemetic Activity of Chemical Compounds," WSEAS Transactions on Biology and Biomedicine, vol. 18, pp. 84-95, 2021, DOI:10.37394/23208.2021.18.10
Vladimir K. Mukhomorov. Statistical Modeling of Antiemetic Activity of Chemical Compounds.
WSEAS Transactions on Biology and Biomedicine. 2021;18:84-95. 10.37394/23208.2021.18.10
WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 18, 2021
Statistical Modeling of Antiemetic Activity of Chemical Compounds
Author:
Abstract: A model has been built linking the molecular structure of drugs with their antiemetic activity. It is shown that the bioactivity of drugs depends on the pseudopotential of the molecule, the information function of the molecule, and the geometric size of the substituents. The critical conditions for the emergence of effective antiemetic activity of molecules have been established. The optimal sizes of the substituents were determined, which correspond to the maximum bioactivity of the drugs. The mechanism of the threshold action of substituted benzamides was revealed.
Keywords:
Antiemetic, statistical criteria, threshold, information function, pseudopotential, linear dimension, benzamides.
Pages: 84-95 WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 18, 2021, Art. #10 DOI: 10.37394/23208.2021.18.10
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