Author(s): Vladimir K. Mukhomorov
Abstract: A model has been built linking the molecular structure of drugs with their antiemetic activity. It is shown that the bioactivity of drugs depends on the pseudopotential of the molecule, the information function of the molecule, and the geometric size of the substituents. The critical conditions for the emergence of effective antiemetic activity of molecules have been established. The optimal sizes of the substituents were determined, which correspond to the maximum bioactivity of the drugs. The mechanism of the threshold action of substituted benzamides was revealed.
Keywords: Antiemetic, statistical criteria, threshold, information function, pseudopotential, linear dimension, benzamides.
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 18, 2021, Art. #10