WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 21, 2024
Uncommon Invasive Penicillium Species Infection in a Patient with Advanced HIV: A Rare Case Report
Authors: , , , , ,
Abstract: Penicillium species are ubiquitous worldwide and constitute one of the largest fungal genera. Typically benign, Penicillium (P.) non-marneffei species can become a serious threat in immunocompromised hosts with the potential for high mortality. We present a rare care of disseminated P. non-marneffei infection in a Honduran patient with advanced HIV, initially manifesting as nonspecific symptoms. After a thorough and unrevealing workup, an inguinal lymph node biopsy resulted in positive fungal staining of tissue. However, expanded polymerase chain reaction (PCR) amplification of fungal 28S rDNA was necessary to confirm the diagnosis. Here we describe the first reported case of disseminated infection in a patient with HIV/AIDS presenting with lymphadenitis and propose treatment recommendations as no standards have been developed yet.
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Keywords: Penicillium non-marneffei, HIV/AIDS, fungal lymphadenitis, disseminated infection, opportunistic infections, PCR, 28S Rrna
Pages: 331-338
DOI: 10.37394/23208.2024.21.33