International Journal of Electrical Engineering and Computer Science
Print ISSN: , E-ISSN: 2769-2507
Volume 1, 2019
Asymmetric Reduction of Prochiral Ketones to Chiral Alcohol by Photo-biocatalysis with Microalgae
Authors: Genghua Chen, Senxiang Zhang, Xinxing Deng, Zhonghua Yang, Fang Yu, Yali Hou
Abstract: The photo-biocatalytic ability of eukaryotic microalgae and prokaryotic microalgae on nonnatural prochiral ketones to produce chiral alcohols was studied in this paper. The results proved that ethyl acetoacetate and acetophenone can be stereo-selectively reduced to the corresponding S-ethyl-3- hydroxybutyrate and S-1-phenylethanol by microalgal photobiocatalysis with high enantioselectivity, respectively. Scenedesmus obliquus has the best photo-biocatalytic effect on ethyl acetoacetate among two eukaryotic microalgae, about 43.98% yield and 69.58% e.e. can be achieved, especially, the culture time is 6 days and light intensity is 9,000lux. Spirulina platensis is the best biocatalyst to acetophenone among four prokaryotic microalgae, about 52.65% yield and 99.40% e.e. can be achieved.The photo-biocatalytic ability of eukaryotic microalgae and prokaryotic microalgae on nonnatural prochiral ketones to produce chiral alcohols was studied in this paper. The results proved that ethyl acetoacetate and acetophenone can be stereo-selectively reduced to the corresponding S-ethyl-3- hydroxybutyrate and S-1-phenylethanol by microalgal photobiocatalysis with high enantioselectivity, respectively. Scenedesmus obliquus has the best photo-biocatalytic effect on ethyl acetoacetate among two eukaryotic microalgae, about 43.98% yield and 69.58% e.e. can be achieved, especially, the culture time is 6 days and light intensity is 9,000lux. Spirulina platensis is the best biocatalyst to acetophenone among four prokaryotic microalgae, about 52.65% yield and 99.40% e.e. can be achieved.
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Keywords: microalgae, asymmetric reduction, Photobiocatalysis, Chiral alcohols
Pages: 61-65
International Journal of Electrical Engineering and Computer Science, ISSN / E-ISSN: / 2769-2507, Volume 1, 2019, Art. #10