WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 11, 2014
Graphical Method to Determine Base Change Locations in Genomic Sequences of Influenza A Virus Using Wavelets
Authors: ,
Abstract: Single base substitutions occur in genomic sequences when a single base gets replaced by another base. These base substitutions are also called point mutations. Mutation detection is important as these are linked to genetic disorders. Several direct and indirect methods are available to detect sequence variation in specific regions of DNA (Deoxyribonucleic acid) sequences. However indirect methods cannot perfectly identify the mutation location in the sequence. Also these methods require mutation confirmation by visual analysis. Thus for automated detection of base substitutions, signal processing methods offer the advantage of simpler, faster and more accurate localisation of point mutations. In this paper, a novel graphical method using wavelet transforms to identify single base changes in H5N1 Influenza A virus has been proposed. The paper discusses the graphical plots of wavelet transformed Hemagglutinin (HA) and Neuraminidase (NA) nucleotide sequences to identify the locations of base changes.
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Keywords: Base substitutions, genomic sequences, wavelet transforms, multiresolution decomposition, Influenza A virus, signal processing
Pages: 70-81
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 11, 2014, Art. #10