WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 11, 2014
Effect of Noise on Estimates of Stepwise Changes in Genome DNA Chromosomal Systems
Authors: , ,
Abstract: Noise accompanying measurements using the high resolution array-comparative genomic hybridization (HR-CGH) array strongly affects estimates of the copy number variations (CNVs) and results in segmental errors as well as in jitter in the breakpoints. Based on the probabilistic analysis and algorithm designed, we show that jitter in the breakpoints can be well approximated with the discrete skew Laplace distribution if the local signalto- noise ratios (SNRs) exceed unity. Using this distribution, we propose an algorithm for computing the estimate upper and lower bounds. Some measurements and estimates tested using these bounds show that the higher probe resolution is provided the more segmental accuracy can be achieved and that larger segmental SNRs cause smaller jitter in the breakpoints. Estimates of the CNVs combined with the bounds proposed may play a crucial role for medical experts to make decisions about true chromosomal changes and even their existence.
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Pages: 52-61
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 11, 2014, Art. #8