WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 13, 2016
The Influence of the Thermodynamic Stacking Constants of Deoxyribo Dinucleotides in the Prebiotic Origin of tRNAs from Bacteriophage T4
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Abstract: Consistent relative deoxyribose dinucleotide stacking thermodynamic interaction energy data is used to predict the composition and complete characterization of a poly deoxyribose nucleotide. When applied to the tRNAs of Bacteriophage T4 they show that the composition of the eight tRNAs of Bacteriophage T4 is closer to that predicted by the Ising model of polynucleotide stacking interactions for the mononucleotide and dinucleotide composition of the anticodon than for the codon indicating the anticodon may have arisen first. The stacking energy for the corresponding ribose anticodon and codon are higher than for the deoxyribose anticodon and codon. The anticodon and codon may be silenced by the synthetic ribose codon and anticodon. The formation of the codon usually requires the sum of the Watson-Crick hydrogen bonding interactions and the stacking interactions to form the complimentary polynucleotide chain. The strand to be most favourably translated is marginally that which favors the formation of the least stable DNA.RNA duplex. The prebiotic codons could not be fully translated without a chance of error. The stability of the DNA anticodons has enhanced their preservation.
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Pages: 95-107
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 13, 2016, Art. #12