WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 14, 2017
Complexes of Lysine Dendrimer of 2nd/3rd Generations and Semax Peptides. Molecular Dynamics Simulation
Authors: ,
Abstract: Complexes of lysine dendrimer and nootropic Semax peptides were studied using molecular dynamics simulation. These dendrimers were used for drug and other molecules delivery to different cells. It was shown earlier that dendrimers and in particular lysine dendrimers could penetrate blood brain barrier. In present paper three systems containing lysine dendrimers of 2nd and 3rd generations and 8, 16 or 24 oppositely charged Semax peptides were studied. It was obtained that lysine dendrimers of both generations attracts Semax peptides and forms stable nanocomplexes with peptides. The sizes and structures of these nanocomplexes were investigated. These complexes can be used in future for delivery of Semax peptides to brain since these peptides have significant neuroprotective effects.
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Pages: 75-82
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 14, 2017, Art. #11