WSEAS Transactions on Biology and Biomedicine
Print ISSN: 1109-9518, E-ISSN: 2224-2902
Volume 16, 2019
Quantitative modeling with Petri nets: perspectives for the target-based treatment of -globin disorders
Authors: ,
Abstract: A novel approach proposed in the present work for alleviating the severity of -globin disorders is centered upon induction of -globin gene expression in fetal hemoglobin and reduction of free and toxic -chains in adult hemoglobin. We use hybrid functional Petri nets in Snoopy framework to create quantitative model of fetal-to-adult hemoglobin switching network and validate its coherence with qPCR data available for existing target-based drug and gene therapies of -globin disorders. Then we apply simulation-based model checking to underlying biological network to predict the most efficient molecular targets for -globin disorders. To measure the effectiveness of -globin disorder treatments we devise a unique criterion, F( ; ; ) = ? ( + ) + c, and justify the reason why this formula can be used as unique criterion. Simulation results show that our approach has potential more beneficial effect on -globin disorders than existing target-based therapies as it minimizes j F j.
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Keywords: Hybrid functional Petri net, quantitative modeling, target-based gene therapy, fetal-to-adult hemoglobin switching network, -thalassemia
Pages: 100-106
WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 16, 2019, Art. #12