wseas-12131-20261001055313-add4ff 20261001055313726 wseas/wseas wseas.group@gmail.com WSEAS Molecular Sciences and Applications 2944-9138 2732-9992 05 14 2026 05 14 2026 6 Jacob Nagler Nagler Independent Research Center NIRC Haifa, Givat Downs 34345, Israel, ISAREL Cell replacement strategies using stem cell-derived photoreceptor precursors (PRPs) offer a promising route for retinal repair; however, a persistent translational bottleneck is the gap between neurite elongation and functional synaptic integration. Recent experimental work combining ROCK inhibition (Y-27632), taurine, retinal conditioned medium, and 3D collagen scaffolds showed pronounced neurite outgrowth, yet transcriptomic readouts at 72 h did not reveal robust presynaptic ribbon marker induction. This manuscript develops a theoretically grounded, multi-scale explanation for that separation between morphology and synaptic maturation. We formulate the Comprehensive Spatiotemporal Elasto-Kinetic (CSEK) framework, extended by the Stochastic Biomechanical Arborization & Transport (SBAT) model, to couple actin cortex relaxation, motor-clutch-based elongation, stochastic branching, and delayed intracellular transport of synaptic cargo. A further Classical Elasto-Kinetic and Reaction-Diffusion (CEK-RD) description is introduced to capture target-cell tethering and compartmental mass transfer. The model predicts that strong elongation can occur well before mature synaptogenesis becomes detectable, especially when contact-dependent transcription and axonal transport delays are superimposed on rapid growth-cone extension. 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